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Della Sala A et al. “Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation.”

Scientific Reports. 20 aprile 2026. DOI: 10.1038/s41598-026-48875-8 Epub ahead of print. PMID: 42009784

Mergiotti Murabito et al. “Targeting PI3Kγ improves CFTR trafficking.”

JCI Insight. 23 marzo 2026. DOI: 10.1172/jci.insight.198846

“PI3K/Akt in IPF: untangling fibrosis and charting therapies”

Bhatt et al (& Hirsch), Frontiers in Immunology

Review

“A nonnatural peptide targeting the A-kinase anchoring function of PI3Kγ for therapeutic cAMP modulation in pulmonary cells”

Della Sala et al (& Ghigo), Journal of Biological Chemistry

Review

“Cell signaling and regulation of CFTR expression in cystic fibrosis cells in the era of high efficiency modulator therapy”

Ghigo et al (&Swiatecka-Urban), Journal of Cystic Fibrosis

Review

“It Takes Two to Tango! Protein–Protein Interactions behind cAMP-Mediated CFTR Regulation”

Murabito et al (& Ghigo), International Journal of Molecular Sciences

Review

“Role of Protein Kinase A-Mediated Phosphorylation in CFTR Channel Activity Regulation”

Della Sala et al (& Ghigo), Frontiers in Physiology

Review

“Therapeutic peptides for the treatment of cystic fibrosis: Challenges and perspectives”

Sala et al (& Ghigo), European Journal of Medicinal Chemistry

Review

“A PI3Kγ mimetic peptide triggers CFTR gating, brochodilation, and reduced inflammation in obstructive airway diseases”

Ghigo et al (& Sala, Hirsch), Science Translational Medicine

Research Article

“A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage”

Lupieri et al (& Ghigo, Hirsch), Journal of Cell Science.

Research Article

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Recent articles

  • Kither Biotech successfully completes Phase 1 clinical trial of KIT2014, a novel inhaled peptide therapy for respiratory diseases
  • Kither Biotech and Pantherna Therapeutics Announce Strategic Collaboration on Synergistic mRNA and Peptide Therapies for Genetic Lung Diseases
  • Kither Biotech Announces Phase 1 Clinical Study Of KIT2014, A Novel Inhaled Peptide Therapy For Cystic Fibrosis
  • Kither Biotech Announces Appointment of Dr. Dimitrios Goundis to Board of Directors
  • Kither Biotech announces publication of new data in Science Translational Medicine

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Kither Biotech
Kither Biotech is a biopharmaceutical company developing signal transduction modulators for the treatment of rare respiratory diseases.
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