Publications
Publications
2000
Jan 2000
“Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation”
Hirsch et al, Science.
2004
Jan 2004
“PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects”
Patrucco et al (& Hirsch), Cell.
2005
Jan 2005
“Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma”
Vecchione et al (& Hirsch), Journal of Experimental Medicine.
2011
Jan 2011
“Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase {gamma} Activity in Pressure Overload-Induced Cardiac Failure”
Damilano et al (& Ghigo, Hirsch), Circulation.
2012
Jan 2012
2017
Jan 2017
“Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs”.
Pirali et al (& Hirsch), ChemMedChem.
2018
Jan 2018
“Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis”
Campa et al (& Sala, Hirsch), Nature Communications.
2020
Jan 2020
“A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage”
Lupieri et al (& Ghigo, Hirsch), Journal of Cell Science.
2022
Mar 2022
“A PI3Kγ mimetic peptide triggers CFTR gating, brochodilation, and reduced inflammation in obstructive airway diseases”
Ghigo et al (& Sala, Hirsch), Science Translational Medicine