Publications
Publications
Della Sala A et al. “Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation.”
Scientific Reports. 20 aprile 2026. DOI: 10.1038/s41598-026-48875-8 Epub ahead of print. PMID: 42009784
Mergiotti Murabito et al. “Targeting PI3Kγ improves CFTR trafficking.”
JCI Insight. 23 marzo 2026. DOI: 10.1172/jci.insight.198846
“PI3K/Akt in IPF: untangling fibrosis and charting therapies”
Bhatt et al (& Hirsch), Frontiers in Immunology
Review
“A nonnatural peptide targeting the A-kinase anchoring function of PI3Kγ for therapeutic cAMP modulation in pulmonary cells”
Della Sala et al (& Ghigo), Journal of Biological Chemistry
Review
“It Takes Two to Tango! Protein–Protein Interactions behind cAMP-Mediated CFTR Regulation”
Murabito et al (& Ghigo), International Journal of Molecular Sciences
Review
“Cell signaling and regulation of CFTR expression in cystic fibrosis cells in the era of high efficiency modulator therapy”
Ghigo et al (&Swiatecka-Urban), Journal of Cystic Fibrosis
Review
“A PI3Kγ mimetic peptide triggers CFTR gating, brochodilation, and reduced inflammation in obstructive airway diseases”
Ghigo et al (& Sala, Hirsch), Science Translational Medicine
Research Article
“Role of Protein Kinase A-Mediated Phosphorylation in CFTR Channel Activity Regulation”
Della Sala et al (& Ghigo), Frontiers in Physiology
Review
“Therapeutic peptides for the treatment of cystic fibrosis: Challenges and perspectives”
Sala et al (& Ghigo), European Journal of Medicinal Chemistry
Review
“A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage”
Lupieri et al (& Ghigo, Hirsch), Journal of Cell Science.
Research Article
“Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis”
Campa et al (& Sala, Hirsch), Nature Communications.
Research Article
“Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs”.
Pirali et al (& Hirsch), ChemMedChem.
Research Article
Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases
Ghigo et al (& Hirsch), Circulation.
Research Article
“Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload-Induced Cardiac Failure”
Damilano et al (& Ghigo, Hirsch), Circulation.
Research Article
“Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ”
Vecchione et al (& Hirsch), Journal of Experimental Medicine.
Research Article
“PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects”
Patrucco et al (& Hirsch), Cell.
Research Article
“Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation”
Hirsch et al, Science.
Research Article